Only those aspects of treatment which differ from routine
practice or are related specifically to dermatology are described.
GENERAL
Washing-Routine washing with
soap and water may do much harm or much good, depending on the particular
disorder being treated. specific instructions must, therefore be given in every
case. In eczematoug and exudative eruptions as a whole washing should be reduced
to a minimum. Soap and water also usually aggravates seborrhoeic dermatitis,
rosacea, and. pityriasis rosea. on the other hand frequent washing forms an integral
part of the treatment of acne vulgarif and daily tar baths are prescribed for
psoriasis. In all other conditions no changes need be made.
Diet- Dietetic treatment is tittle used in
dermatology' occasionally some food, substance may be the cause of urti-caria
and must therefore be eliminated. on the other hand, food and. drink play no
part in either infantile eczemlu or any other eczematous Lruption. It is
traditional to restrict the intake of carbohydrates in seborrhoeic dermatitis
and chocolate in acne vulgaris, though usually little discernible improvement
results. Any food or drink which normally tends to cause flushing, such as hot
tea, spiced food or alcohol, will temporarily aggravate rosacea, but has no
permanent effect. A reducing diet is probabty the most, useful dietetic weapon as
many dermatological patients are over-weight and this materiaily aggravates
their maladies. Finally a particular type of low fat diet may be used in the
treatment of xantha- matosis
DRUGS-Systemic treatment is playing a larger and larger part in
dermatology. specific drugs used in the treatment of individual diseases are
described in the section dealing with those diseases. The following remarks
concern the particular use in dermatology of drugs common to the whole of
medicine.
Antipruritics- There is, unfortunately, no
drug which has a specific effect on itching. some decrease of this symptom can
hover be obtained by the judicious use of sedatives and antihistamines.
Sedatives-These are
extensively used to reduce tension, to relieve itching and to obtain sleep.
Small doses, such as phenobarbitone, mg. 16 to 30 (gr.1/4 to 1/2) or amytal mg. 50 (gr. 3/4), may be
given two or three times through the day and larger doses may be given at
night. If itching is severe, very large doses at night often only decrease the
patient's ability to refrain from scratching, without inducing sleep.
Tranquillisers have on the whole proved disappointing, although .hlotoptomazine
(Largactil) and chlordiaziepoxide (Librium) are sometimes helpful, as are some
of the newer phenothiazine derivatives.
Antihistamines do not prevent the
liberation of histamine but, as the name indicates, inhibit its action. They
also have a mild antipruritic effect which is quite separate from their
antihistaminic action and which therefore can be utilised in other conditions. The different, compounds in this group
vary in their length of action and in the intensity of their sedative effect.
chlorpheniramine maleate (Piriton), cyproheptadine hydrochloride (Periactin)
and triprolidine hydrochloride (Actidil) for instance are effective for about 4
hours and have a moderate sedative effect, which tends, as is the case with all
members of this group of drugs, to become less marked the longer the substance
is given. on the other hand, promethazine (Phenergan) exerts its effect for
about 12 hours and, because it also has a marked. hypnotic effect, is best
given last thing at night. The majority of these compounds are also available
in the form of an elixir for the treatment of children and as injections for
intramuscular or intravenous use. There are a great number of antihistamine
drugs available and new ones are constantly being produced. Efrorts are now
being concentrated on their antipruritic properties and trimeprazine, which is
given in doses of l0 mg. three or four times a day, is one of the first
marketed for this purpose. It has a definite, though unfortunately only slight,
effect on itching. None of these substances have any antihistaminic effects
when apptied locally, although they are markedly antipruritic when used in this
way. Nevertheless, they should never be employed topically because of their
sensitizing properties and the consequent risk of causing dermatitis.
Antibiotics
Bacterial. systemic antibiotics are less
frequently required in dermatology than in other branches of medicine,since it
is possible to control most, infections by local applications. when systemic
therapy is necessary, penicillin remains the first choice, since the
staphylococcus is by far the commonest infecting organism, being present in
pure culture in over 60% of all infective conditions and in mixed culture in
over 90%. The increasing number of resistant strains must however be borne in
mind and these occur in about staphylococci, cloxacillin, areg enerally
effective and it is rarely necessary to use chloramphenicol or any of the
erythromycin group. The long-term use of penicillin in recurrent erysipelas and
tetracycline in acnev ulgaris is dealt with in the sections dealing with those
diseases. In choosing a loeal antibiotic three things must be borne in mind,
the sensitivity of the organism, the potency of the antibiotic and its irritant
effect on the skin. Thus penicillin and streptomycin are never used locally,
since they so frequently cause a
sensitisationre action. Bacitracin and tyrothrycin are relatively weak
antibiotics and of little use when used alone. The tetracyclines and
erythromycins should not be used topically unless they are specifically
indicated since, becauset hey are needed to combat serious systemic infections,
every effort must be made to avoid increasing resistant strains of organism by
unrlecessary use. This does not apply nearly so forcibly to chloramphenicol,
but here the chanceso f causing a sensitisation dermatitis are greater than
with the latter groups of antibiotics, but much less than with penicillin or
streptomycin. The antibiotics of choice for external use are those which are
never used systemically, namely neomycin, soframycin and polymyxin. The first
two are available as ointments or lotions and control the great majority of
infective conditions. If they fail and adequate bacteriological investigation
is unavailable a change should be made
to chloramphenicol, especially as it is effective against most of the gram-negative
organisms. Polymyxin, although very effective against staphylococci, should be
exclusively reservedf or the treatment of infections due to pseudomonas
pyocyanea. It is available as an ointment (Polyfax) and as a lotion
(Otosporin).
Fungal. Nystatin, an artibiotie isolated
from a strepto-myces, has a specific action against caniliila albieans
(monilia). It may be prescribed in the form of an ointment, suspension, or ear
drops (dissolved in propylene glycol), in a strength of 100,000international units per gram or millilitre, and as tablets
(500,000 units per tablet) for oral use. The latter are not absorbed and only
exert, their effects against candida in the gut. Amphoterecin B, obtained from
streptomyces nodosus, is also effective against candida. It is used either
locally or as a slow intravenous injection for systemic cases.